A boy is struck down with a strange condition. A woman has bizarre symptoms that push her to the brink of madness. A toddler falls into a trance-like state.

A teenager develops mysterious blotchy sores. A tough athlete is struck down by a rare disease. A woman battles strange bouts of vomiting.

A man starts coughing up blood. A newlywed husband is struck down by a rare disease. A young father experiences crippling abdominal pain.

An infant is suddenly paralyzed. A young father grapples with a monster that threatens to blind him. A woman's excruciating pain confounds experts.

A young woman is struck down by a dangerous parasite. An infant becomes mysteriously ill. A Midwestern man is brought to the brink by a deadly fungus.

Three unwanted Christmas surprises. A man bangs his head and is left fighting a one-in-a-million medical mystery. A wound in a boy's knee harbors an uninvited guest. And a man unwittingly feeds his own intended killer.

A man develops a strange growth on his wrist. A nurse sees twig-like pieces in her urine. A pregnant woman falls dangerously ill with flu-like symptoms.

Bobo, Cliff, Matt and Ranae travel to the forests of northern Georgia to examine footage of what could be a Bigfoot running across the road.

The team heads to northern Florida to help a family that believes they have a Bigfoot living on their property, then they meet with members of the Seminole nation, whose history with the creature goes back hundreds of years.

From deep inside the NC Uhwarrie National forest comes one of the most convincing pieces of Bigfoot footage from the past 40 years. Investigators use decades worth of experiences to determine if this footage is the real deal.

The specialists head to Oregon to examine a video taken on a rafting expedition. While investigating, the team hears a sound in the middle of the night that they believe could prove the creature's existence.

The investigators journey into the mountains of southern Washington to explore a series of photos that depict what some believe is a Bigfoot on a snowy peak.

A call from a concerned mayor brings the team of experts to the island of Prince of Wales, Alaska. The island has a long history with the beast, but a recent spike in activity has the townspeople on edge.

Bobo, Cliff, Matt and Ranae return to Oregon to participate in their favorite event, Bigfoot and Beer. The team reflects on their expeditions, answers questions and shares some never-before-seen moments.

The team heads to New York to investigate video of an alleged baby Bigfoot. When locals report activity in the neighboring woods, the team tries a new search method in hopes of finding Bigfoots near the Big Apple.

The investigators go to Rhode Island to examine video of a roadside sighting of a Bigfoot. They learn that this unexplored area has a wealth of Sasquatch activity and hope to prove that this small state is hiding Bigfoots.