Houston welcomes veterinarians Dr. Blue, Dr. Ross and Dr. Lavigne, who have their hands full with everything from risky surgeries to diagnosing sick chameleons. A car accident brings the practice to a halt as one of the doctors faces a long recovery.

Dr. Ross is back at the clinic, but a check-up with a large pet proves to be too much too soon. When a pregnant Frenchie goes into early labor, Dr. Lavigne performs an emergency c-section. Dr. Blue plans a Texas outing to help lift Dr. Ross' spirits.

While Dr. Blue & Dr. Ross help a client at their goat farm, Dr. Lavigne must save a pup with an obstruction in his intestines and a concerned family waiting. Dr. Blue & Dr. Ross compete in a cook-off to see who is the best grill master.

Dr. Ross buys a mobile unit for community outreach and Dr. Blue enlists his brother to help deck it out. Back at the clinic, Dr. Ross examines an iguana for an abscess and Dr. Lavigne helps a paraplegic dachshund get a new set of wheels.

Flooding has sent Houston into a state of emergency. While the clinic takes in displaced animals, Dr. Blue treats a puppy that has contracted a disease from standing water. Dr. Lavigne and Dr. Ross examine a tiger found wandering in a neighborhood.

Dr. Ross performs a life-altering surgery on a sweet pup given a second chance at life, while Dr. Lavigne examines a prickly pet. After treating an injured owl, Dr. Blue joins Dr. Ross on farm to examine a cute litter of tiny piglets that are sick.

Dr. Lavigne must remove tumors from an older dog, while Dr. Ross tries to save a rabbit's foot that's been damaged by a dog attack. Before he can compete with Dr. Ross in a puppy-training competition, Dr. Blue has to castrate an aggressive donkey.

The clock is ticking as Dr. Blue performs an emergency C-section on a mother with two puppies stuck in her uterus, while Dr. Ross and Dr. Lavigne work on pets with serious eye issues.

Dr. Ross treats baby kangaroos and works with the owners of a petting zoo to hold a fun event at the clinic to promote animal awareness. Dr. Blue removes a mass from a beloved pit mix, and Dr. Lavigne treats a vision and hearing impaired Great Dane.

A health scare puts the brakes on Dr. Blue's dreams of motorcycle riding with his brother. Dr. Ross treats a sweet bearded dragon who is laying bad eggs, while Dr. Lavigne is challenged with what to do about a large tumor taking over a Boxer's toe.

The time has come for Dr. Ross & Tauvia to move out of his mama's house. Dr. Lavigne makes a life or death decision with Diesel, a mastiff who could have a toy lodged in his intestines. Dr. Blue sees a pig with an affection for household furniture.

Dr. Ross and vet tech Kyerra rush to save a stray cat that's been brutally mangled by a car engine. The Ross' move into their new home while Dr. Blue treats a 700 lb. arthritic pig. Dr. Lavigne sees a rescue Chihuahua with an incredible story.

Dr. Blue uncovers a big problem for a paralyzed Yorkie. Dr. Ross sees to a pair of roosters involved in a barnyard brawl before joining Dr. Lavigne on a hyena consultation. The Lavigne family hosts a dinner party showcasing Anne's cooking skills.

The doctors battle it out to determine who will go to a vet conference in San Diego. Dr. Ross treats a kinkajou nearing his terrible twos, while Dr. Blue rids a Min Pin of drop dead breath. Dr. Lavigne suspects a cat has a contagious disease.

Dr. Blue needs to act fast when a Rottweiler in labor is rushed into the hospital with two puppies stuck inside her. Then, the three vets grab the reins and their cowboys hats to ride horseback into town for Houston's biggest rodeo parade.

The docs visit their alma mater for a class reunion and become professors for a day. A Shih Tzu is rushed to the clinic after swallowing a large piece of rawhide while the owner of pit bull with a deformed leg must consider drastic surgery.